1、overall survival

overall survival發(fā)音

英：　　美：

overall survival中文意思翻譯

常用釋義：總生存期：指從治療開始到患者死亡或最后一次隨訪的時(shí)間。

[醫(yī)]總存活數(shù)，總生存數(shù)

overall survival雙語使用場(chǎng)景

1、overall survival curves of the 2 cohorts were superimposable, the researchers commented.───研究人員評(píng)論說，這兩個(gè)隊(duì)列的總體生存曲線是可疊加的。

2、The secondary endpoints included overall survival, overall response rates, and safety profile.───次要終點(diǎn)包括整個(gè)生存期 、 整體反應(yīng)率和安全情況.

3、Conclusions Our five - gene signature is closely associated with relapse - free and overall survival among patients with NSCLC.───結(jié)論:我們的五個(gè)基因標(biāo)記與非小細(xì)胞肺癌患者的無復(fù)發(fā)及總生存率密切相關(guān).

4、The 5 - year overall survival ( OS ) and disease free survival ( DFS ) were 89 % and 73 %, respectively.───全組5年總 生存率 和無病生存率分別為89%和73%.

5、Overall survival after two years was similar among both groups—88% on the drug versus 80% on placebo.───兩組患者兩年后的總存活率相似，服藥組為88％，服用安慰劑組為80％。

6、As noted, however, no significant difference in overall survival was seen between the groups, with a median survival period for each of about 26 months.───然而，正如已經(jīng)提到的，在各組之間沒有看到總體存活率的顯著性差異，中值存活期分別為約26個(gè)月。

7、The five - gene signature was an independent predictor of relapse - free and overall survival.───這五個(gè)基因是對(duì)無復(fù)發(fā)和總生存率的獨(dú)立預(yù)測(cè)指標(biāo).

8、Results The overall survival rate recovery with function was 85 %.───結(jié)果再植后成活率達(dá)93%,按斷指再植療效評(píng)定標(biāo)準(zhǔn)優(yōu)良率達(dá)85%.

overall survival相似詞語短語

1、improve survival───提高生存率

2、overall trend───總體走向；總體趨勢(shì)

3、overall sales───營(yíng)業(yè)總收入；整體銷售額

4、overassertive───過度評(píng)價(jià)

5、jealous rival───嫉妒的對(duì)手

6、overall total───綜合總計(jì)

7、mere survival───僅僅是生存

8、overall design───總體設(shè)計(jì)；總設(shè)計(jì)

9、overall budget───總體預(yù)算

2、pfs和os的區(qū)別？

PFS無進(jìn)展生存期；OS總生存期。

1、無進(jìn)展生存期（Progression-Free Survival）

PFS是指為從隨機(jī)化至出現(xiàn)腫瘤客觀進(jìn)展或全因死亡的時(shí)間，是OS的替代終點(diǎn)。與OS相比，PFS的終點(diǎn)前移至“發(fā)生進(jìn)展”，這個(gè)時(shí)間節(jié)點(diǎn)往往早于死亡，因此PFS常常短于OS，隨訪時(shí)間更短，可以間接反映患者的臨床獲益。

2、總生存期（Overall Survival，OS）

OS是指從隨機(jī)化到任何因素導(dǎo)致患者死亡的時(shí)間。OS的判定精確可靠，不易偏倚，被認(rèn)為是最佳的療效終點(diǎn)。因?yàn)榛颊叩乃劳鋈掌谠诖_認(rèn)上基本沒有困難，并且如果結(jié)果顯示生存有所提高，就可以認(rèn)為該抗腫瘤藥有直接的臨床獲益。但是OS常需較大樣本量和更長(zhǎng)的隨訪時(shí)間，易受到交叉和后續(xù)治療影響。

值得一提的是，只有OS是基于患者死亡事件描述的臨床終點(diǎn)，其余的指標(biāo)均是基于腫瘤測(cè)量的終點(diǎn)。