?convening

convening發(fā)音

[kən'vi:n]

英：　　美：

convening中文意思翻譯

vt.集合, 召集, 召喚

vi.集合

convening詞形變化

形容詞: convenable | 名詞: convener | 動(dòng)詞過去式: convened | 動(dòng)詞第三人稱單數(shù): convenes | 動(dòng)詞現(xiàn)在分詞: convening | 動(dòng)詞過去分詞: convened |

convening同義詞

opportunely | suitably | accessibly | usefully | handily | appropriately | expediently

convening反義詞

inconveniently

convening常見例句

1 、Olympics also contributed to the convening of Shuangliu airport, the rising standards of air defense protection.───奧運(yùn)會(huì)的召開也促使雙流機(jī)場(chǎng)的空防保障水平不斷提升。

2 、The Delegation of Nicaragua supported the convening of a diplomatic conference in 2007, if possible.───尼加拉瓜代表團(tuán)支持在可能時(shí)于2007年召集一次外交會(huì)議。

3 、In the meantime, the society is convening a panel to provide guidelines to doctors.───與此同時(shí)，該學(xué)會(huì)正考慮召集一次公開討論會(huì)以便為醫(yī)生提供指導(dǎo)。

4 、We must convene a tribunal and execute him.─── 我們一定要審判他 處決他

5 、The minister shall be in charge of convening and presiding over the ministerial meeting, the minister's executive meeting, the minister's communication meeting and other important meetings.───六、部長(zhǎng)召集和主持部務(wù)會(huì)議、部長(zhǎng)辦公會(huì)議、部長(zhǎng)碰頭會(huì)議和其他需要召開的重要會(huì)議。

6 、April 1990, French President Francois Mitterrand and German Chancellor Helmut Kohl, in a joint initiative of the end of the convening of the political alliance of the intergovernmental meeting.───1990年 4 月，法國(guó)總統(tǒng)密特朗和聯(lián)邦德國(guó)總理科爾聯(lián)合倡議于當(dāng)年底召開關(guān)于政治聯(lián)盟問題的政府間會(huì)議。

7 、These institutions cannot be trusted, so we are convening our own court.─── 這些機(jī)構(gòu)無法被信任 因此我們將召開自己的法庭

8 、China took an active part in the preparations for and in attending the UN Conference on Environment and Development. It made great efforts for the smooth convening of the Conference.───中國(guó)積極參與籌備并出席了聯(lián)合國(guó)環(huán)境與發(fā)展大會(huì)，為大會(huì)的順利召開作出了努力。

9 、" A conven tional fuel cell is a big stack of graphite plates you squeeze together,and you're got all these gaskets and things",he says.───他說：“傳統(tǒng)的燃料電池是一大堆擠壓在一起的石墨板，而我們又不缺生產(chǎn)墊板這類的材料，所以我們就用像印制電路這樣的方式重造燃料電池?！?/p>

10 、China supports convening a high-level UN conference on the MDGs next year and hopes that this will help mobilize the political wills and resources of all sides for the MDGs.───中方對(duì)明年召開聯(lián)合國(guó)千年發(fā)展目標(biāo)高級(jí)別會(huì)議的倡議持積極態(tài)度，希望有關(guān)會(huì)議有利于動(dòng)員各方政治意愿與資源。

11 、Convening shareholders'meetings and reporting the status on work thereto;───召集股東會(huì)會(huì)議,并向股東會(huì)報(bào)告工作;

12 、It is storied that when convening the first Council of Cakravala in the Rajagraha, he read out all the sutras starting with “Thus I have heard...───相傳在王舍城第一次結(jié)集時(shí)，就是由阿難誦出了全部經(jīng)藏，漢譯佛經(jīng)第一句“如是我聞”，就是阿難所說。

13 、The Realistic Condition and the Problem Optimization of Public Hearing Convening in our Country───我國(guó)聽證召集程序現(xiàn)實(shí)狀況與問題優(yōu)化

14 、YunFu city convening the spot meeting of mulberry planting and silkworm rearing───云浮市召開種桑養(yǎng)蠶工作現(xiàn)場(chǎng)會(huì)

15 、Any Power exercising this right must notify its intention to the other Powers, through the Belgian Government, which will make arrangements for convening the Conference within six months.───彼此通知有關(guān)的法律：各締約國(guó)應(yīng)將為履行前款規(guī)定而已在其本國(guó)頒布或今后擬予頒布的法律或規(guī)章，盡速互相通知。

16 、The so-called G-20 nations, representing most of the world's economy and population, are convening with the knowledge that they will sink or swim together.───號(hào)稱20國(guó)組織，代表全世界里有最經(jīng)濟(jì)能力和最多人口的20個(gè)國(guó)家，知道他們這次必須同舟共濟(jì)而聚集在一起。

17 、He's managed to convene a meeting for later today.─── 今天晚些時(shí)候他會(huì)召集所有成員開會(huì)

18 、Of the reasons for the departments concerned not convening promotion boards for such acting appointments to identify the most suitable candidates for promotion?───為何有關(guān)部門不就有關(guān)的署任職位召開晉升選拔委員會(huì),讓最合適的人員獲得晉升?

19 、Furthermore, the Delegation recalled the decision by the SCCR at its 15th session, to recommend the convening of a diplomatic conference on a treaty for the protection of broadcasting organizations.───此外,該代表團(tuán)回顧了SCCR在第十五屆會(huì)議上建議召集關(guān)于保護(hù)廣播組織條約的外交會(huì)議的決定。

20 、All the conditions are ripe for convening the Political Consultative Conference and forming a democratic coalition government.───召集政治協(xié)商會(huì)議和成立民主聯(lián)合政府的一切條件，均已成熟。

21 、Chinese sports industry will be convening a meeting, which has been circulating on Guojun will serve as the Olympic Garden, Sports Management Limited brand news finally confirmed.───中體產(chǎn)業(yè)召開記者見面會(huì)，此前已經(jīng)流傳的關(guān)于郭鈞將擔(dān)任中體奧林匹克花園品牌管理有限公司總裁的消息終于得到證實(shí)。

22 、The public announcement and notice shall stipulate the date of the first convening of the creditors' meeting.───公告和通知中應(yīng)當(dāng)規(guī)定第一次債權(quán)人會(huì)議召開的日期。

23 、It supported the convening of a diplomatic conference in 2007 since new problems would emerge if it were delayed.───如果耽擱,將出現(xiàn)新問題,因此它支持在2007年召集一次外交會(huì)議。

24 、Both parties considered that the convening of the conference was desirable.───雙方都認(rèn)為召開這次會(huì)議是可取的。

25 、We'll convene in my bedroom near the witching hour.─── 巫聚時(shí)辰前在我的臥室集合

26 、The recent convening of the United Nations World Summit for Social Development in Copenhagen bore witness to the need for the world community to pool their efforts to fight poverty.───最近在哥本哈根召開的聯(lián)合國(guó)社會(huì)發(fā)展世界首腦會(huì)議，已認(rèn)識(shí)到國(guó)際社會(huì)攜起手來迎戰(zhàn)貧窮的必要性。

27 、I'd like to take the opportunity of the opening of the China Development High-Level Forum to extend my warm welcome to friends from various countries and also my heartfelt congratulations to the convening of the forum.───值此“中國(guó)發(fā)展高層論壇”開幕之際，我謹(jǐn)向參加論壇的各國(guó)朋友、各位來賓表示熱烈的歡迎，對(duì)本次論壇的舉辦致以衷心的祝賀！

28 、Vic directional drilling technique refers to a methed of directional drilling using Vic Drill-Headwtihout conven tional whipstocks.───Vic定向鉆進(jìn)技術(shù)是采用Vic定向鉆具進(jìn)行定向鉆進(jìn)的一種方法。

29 、" A conven tional fuel cell is a big stack of graphite plates you squeeze together, and you're got all these gaskets and things", he says.───他說：“傳統(tǒng)的燃料電池是一大堆擠壓在一起的石墨板，而我們又不缺生產(chǎn)墊板這類的材料，所以我們就用像印制電路這樣的方式重造燃料電池。

30 、During his meeting with Chen, he praised China for timely convening the Asian region dialogue on water and sanitation which was attended by him also during his visit.───在于陳部長(zhǎng)會(huì)晤時(shí)，他稱贊中國(guó)能及時(shí)召開“水與衛(wèi)生亞洲地區(qū)對(duì)話會(huì)”。他本人在訪問中國(guó)期間也參加了此次對(duì)話會(huì)。

31 、The convening of the European Central Bank Governing Council meeting on interest rates and interest rates announced resolution.───歐洲中央銀行管理委員會(huì)召開議息會(huì)議，并公布利率決議。

32 、By convening the G20 rather than the closed, rich club of the G7, the old order has in effect acknowledged that the rest of the world has become too important to bar from the room.───召開二十國(guó)峰會(huì)而不是七國(guó)峰會(huì)，這就意味著舊的秩序?qū)嶋H上已經(jīng)承認(rèn)其它世界其它國(guó)家已經(jīng)變得非常重要而不能拒之門外了。

33 、All right, I'll convene an ethics committee.─── 好吧 我來召開道德委員會(huì)的會(huì)議

34 、In this background the convening of this conference is to use concrete actions to support the revitalization of northeast China strategy.───在這樣的大背景下召開這個(gè)會(huì)，就是用實(shí)際行動(dòng)對(duì)振興東北戰(zhàn)略的支持。

35 、There are also things, such as the convening of the Border Region Assembly, which we shall do without reporting for the time being, knowing that the Kuomintang will not agree.───有些則暫時(shí)斬而不奏，估計(jì)它現(xiàn)時(shí)不會(huì)同意，例如召集邊區(qū)議會(huì)之類。

36 、A Probe into the Convening of Temporary Conference of Shareholders───淺析股東會(huì)臨時(shí)會(huì)議的召集

37 、We're for convening the conference to seek a peaceful settlement of the probtem.───我們贊成召開這次會(huì)以謀求這問題的和平解決。

38 、China took an active part in the preparations for and in attending the UN Conference on Environment and Development.It made great efforts for the smooth convening of the Conference.───中國(guó)參加了聯(lián)合國(guó)環(huán)境與發(fā)展大會(huì)的歷次籌備會(huì)議，在討論和談判國(guó)際環(huán)境公約時(shí)發(fā)揮了建設(shè)性的作用。

39 、Keeping Mr Irving in jail at most may stop him going to a conference that Mr Ahmadinejad is convening to "rewrite and revise" the history of the holocaust.───把歐文先生關(guān)在牢里也許頂多可以阻止他參加一個(gè)由艾哈邁迪?內(nèi)賈德總統(tǒng)推動(dòng)的旨在“改寫和修訂”有關(guān)大屠殺的歷史學(xué)術(shù)會(huì)議。

40 、On behalf of the Chinese government, I would like to extend our sincere welcome to all the guests here and to express our warm congratulations on the convening of this session.───我代表中國(guó)政府，向各位來賓表示誠(chéng)摯的歡迎！向大會(huì)表示熱烈的祝賀！

41 、Convening the sessions of the owners'congress, and reporting the implementation of the realty management;───召集業(yè)主大會(huì)會(huì)議,報(bào)告物業(yè)管理的實(shí)施情況;

42 、"We tortured Qathani," Susan Crawford, the convening authority of military commissions, said.───受審的軍方委員會(huì)官員蘇珊.克勞福這么說。

43 、They look forward to convening the third UK-China Internet Roundtable in U.K in 2010.───雙方期待2010年在英國(guó)舉辦第三屆中英互聯(lián)網(wǎng)圓桌會(huì)議。

44 、convening authority───傳喚權(quán)

45 、CONVENING THE FORUM ON WORK OF SMES ALL OVER THE COUNTRY IN BEIJING───全國(guó)中小企業(yè)工作座談會(huì)在京召開

46 、public hearing convening───聽證召集

47 、Here, let me, on behalf of the Ministry of Construction, to the convening of the meeting of the Shanghai low-cost housing pilot project achievements expressed warm congratulations.───在此，我代表建設(shè)部，對(duì)這次會(huì)議的召開，對(duì)上海市廉租住房試點(diǎn)工作取得的成績(jī)表示熱烈的祝賀。

48 、The number of delegates to such conferences and the procedure governing their election shall be determined by the Party committees convening them.───代表會(huì)議代表的名額和產(chǎn)生辦法，由召集代表會(huì)議的委員會(huì)決定。

49 、Once we convene, there will be no judge.─── 一旦我們召集起來 就沒有法官

50 、State which would exercise this right should notify its intention to the other States through the Belgian Government, which would make arrangements for convening the Conference.───欲行使此項(xiàng)權(quán)利的國(guó)家，應(yīng)通過比利時(shí)政府將其意圖通知其他國(guó)家，由比利時(shí)政府安排召開會(huì)議事宜。

51 、"My government fully supports the immediate convening of a Security Council meeting tomorrow New York time," Ban said in a meeting with US ambassador Alexander Vershbow.───潘基文在與美國(guó)駐韓大使亞歷山大·弗什鮑的會(huì)談中表示:“韓國(guó)政府絕對(duì)支持安理會(huì)將于明天在紐約召開的安理會(huì)緊急會(huì)議。

52 、You don't have enough to convene a grand jury.─── 你還沒有足夠召集陪審團(tuán)的證據(jù)

53 、Seminar of Chinese Fishery Position Convening in Beijing───全國(guó)漁業(yè)經(jīng)濟(jì)形勢(shì)研討會(huì)在京召開

54 、The odyssey began on the shores of Honolulu, the Lakers convening for training camp without knowing what awaited them, other than a slew of grim possibilities.───故事還得從檀香山的海濱說起。湖人隊(duì)在那兒集結(jié)訓(xùn)練，除了知道也許有一線轉(zhuǎn)機(jī)之外，卻不知等待他們將是什么。

55 、Thank you for convening this meeting and launching the flash appeal for Haiti.───感謝你召集這次會(huì)議，為援助海地發(fā)起緊急呼吁。

56 、The Economic and Social Council shall meet as required in accordance with its rules, which shall include provision for the convening of meetings on the request of a majority of its members.───二、經(jīng)濟(jì)及社會(huì)理事會(huì)應(yīng)依其規(guī)則舉行必要之會(huì)議。此項(xiàng)規(guī)則應(yīng)包括因理事國(guó)過半數(shù)之請(qǐng)求而召集會(huì)議之條款。

57 、It was in favor of the convening of a diplomatic conference in July 2007.───它支持在2007年7月召集一次外交會(huì)議。

58 、The partners' meeting shall be formed by all partners. The form, convening method and vote measures shall be stipulated by the partnership agreement.───合伙人會(huì)議由全體合伙人組成，合伙人會(huì)議的形式、召集方式和表決辦法等由合伙協(xié)議約定。

59 、Recently, Shanxi government works, and the convening of the liquidation of arrears of wages for farmers teleconference on the "double -" work to mobilize and re-deployment.───日前，山西省人民政府召開清理拖欠工程款和農(nóng)民工工資電視**會(huì)議，對(duì)“雙清”工作進(jìn)行再動(dòng)員、再部署。

60 、The WHO was convening an expert panel to consider whether to raise the pandemic alert level or issue travel advisories.───世衛(wèi)組織正在召開一個(gè)專家小組，以考慮是否提高流行病警戒級(jí)別或問題旅行忠告。

61 、Well, it wasn't dark when I was convening.─── 我來親近自然的時(shí)候天還沒黑

62 、The Liquidators will be convening a meeting of the creditor of the Company under Section 179(1) of the Act.───清算人將依照破產(chǎn)清算法179(1)條召開債券人會(huì)議。

63 、Now I am most looking forward to and is excited about 2008 in China's capital - Beijing, the convening of the 29th Games.───現(xiàn)在最令我期待和興奮的是2008年即將在中國(guó)的首都--北京，召開的第29屆運(yùn)動(dòng)會(huì)。

64 、The convening of the Hopei Provincial Assembly and the elections to the Hopei Administrative Council,preparations for which have just been started,will be of exceptional importance.───目前正在開始的召集河北參議會(huì)和選舉河北行政委員會(huì)，是一件具有嚴(yán)重意義的事。

65 、Parasitical thermal radiation loss is one of the main factors which greatly influences the thermal-to-electric convening efficiency of AMTEC.───寄生熱輻射損失特別是BASE管外表面的熱輻射是影響堿金屬熱電轉(zhuǎn)換器高效運(yùn)行的主要因素之一。

66 、In this respect, Malaysia supported the recommendation of the 15th SCCR to convene the Diplomatic Conference and fully supported the convening of a two-day special meeting in January 2007.───在此方面,馬來西亞支持SCCR第十五屆會(huì)議有關(guān)召集外交會(huì)議的建議,并完全支持2007年1月召集為期兩天的特別會(huì)議。

67 、The spec. is unity, capacity is stable, the goods which is stored is clear, so it is conven...───發(fā)布者：陳麗娜所在地：山東青島市行業(yè)：機(jī)械及行業(yè)設(shè)備職位：外銷員工作年限：二年以上

68 、Luxembourg is convening European Union minister of foreign affairs meets rescues the city motion to Eurozone to extend welcome jointly at the same day.───正在盧森堡召開的歐盟外長(zhǎng)會(huì)當(dāng)天對(duì)歐元區(qū)聯(lián)合救市行動(dòng)表示歡迎。

69 、Another major operation as a result of the friendship network shares in the Shanghai area, would significantly benefit from the convening of the world fair.───另外由于友誼股份主要經(jīng)營(yíng)網(wǎng)點(diǎn)分布在上海地區(qū)，將顯著受益于世博會(huì)的召開。

70 、How can it muster the convening power that brings 80 nations to Annapolis?───又如何能鼓起召開會(huì)議的權(quán)力，使80個(gè)國(guó)家，以安納波利斯？

71 、An action may be taken by the board of directors without the convening of a board meeting if all the members of the board of directors consent in writing to the action.───如果全體董事書面同意，董事會(huì)可以不召開會(huì)議而采取行動(dòng)。

72 、General Court-Martial Convening Authority───最高軍事法庭開庭授權(quán)

73 、The convening of each unit party committees (Party branches) will be the topic of "Mapping Safety Production Month" activities carried out conscientiously.───各單位召開黨委（支部）專題會(huì)，對(duì)“測(cè)繪安全生產(chǎn)月”活動(dòng)進(jìn)行認(rèn)真部署。

74 、conven tional triaxial test───常規(guī)三軸試驗(yàn)

75 、After the conference, Britian also brought Italy into the protrolling system by convening Anglo-French-Italian naval talk.───會(huì)議結(jié)束后，通過召開英、法、意三方海軍會(huì)談，英國(guó)還將意大利拉入海軍巡邏體系中來。

76 、"When convening the assembly, however, you shall blow without sounding an alarm.───民10:7但招聚會(huì)眾的時(shí)候、你們要吹號(hào)、卻不要吹出大聲。

77 、The SCCR had taken premature action in recommending the convening of a diplomatic conference where there was no consensus on important issues.───在尚未就許多重要問題達(dá)成協(xié)商一致的情況下,SCCR建議召集一次外交會(huì)議為時(shí)過早。

78 、And it is also a snub to China, which has been convening the six-way effort.───同時(shí)這也是對(duì)中國(guó)籌措六方會(huì)談努力的怠慢。

79 、My delegation is not satisfied that the case has yet been made for convening such a broad conference.───我方代表團(tuán)覺得這件事情被提請(qǐng)到這么大的會(huì)議上討論是不合時(shí)宜的。

80 、We have proposed the convening of a provisional national assembly, which is likewise both necessary and possible.───我們提出了召集臨時(shí)國(guó)民大會(huì)的方針，這也是必要的和可能的。

81 、You not only travel and leisure resort homes a good place, or the convening of conferences, business meetings of the ideal.───不僅是您外出旅游度假休閑居停的好場(chǎng)所，還是召開各種會(huì)議、商務(wù)洽談的理想之地。

82 、" Some developers festive occasion of the convening of customers Association, also received very good results.───另一些開發(fā)商借節(jié)日之際召開客戶聯(lián)誼會(huì)，也收到了很好的效果。

83 、Adjust the program to be made early this week will be a member of the convening of the meeting submitted to the UAW local union leaders.───擬作出的調(diào)整方案將在本周初召開的委員會(huì)議上提交給UAW地方工會(huì)**。

84 、Planning of Convening Farmland into Forest or Grass Land Based on GIS Spatial Analysis───GIS空間分析在退耕還林中的應(yīng)用研究

85 、China participated in the 1998 UN Group of Governmental Experts on Small Arms. It supports the convening of the International Conference on the Illicit Trade in Small Arms and Light Weapons in All Aspects in 2001.───中國(guó)參加了1998年聯(lián)合國(guó)小武器問題政府專家組的工作，支持于2001年召開小武器和輕武器非法貿(mào)易各方面問題的國(guó)際會(huì)議。

86 、Limited referred to in the Notice convening the second Creditors' Meeting.───委托期限為本授權(quán)委托書簽發(fā)日至第二次債權(quán)人會(huì)議結(jié)束。

87 、He deserves credit for convening the G20 meeting in London, and for Britain's pioneering bank rescues and useful budgetary stimulus (in noted contrast to the Tories' proposals).───在倫敦召開20國(guó)會(huì)議及英國(guó)率先采取銀行救市和有效預(yù)算刺激（與保守黨的建議形成鮮明對(duì)比），他理應(yīng)得到贊揚(yáng)。

88 、If we say that for this reason the choice of building cooperation, we contact the owners in the community, proposed the convening of the meeting of the owners more directly.───如果說，因?yàn)檫@個(gè)原因而選擇合作建房，倒不如在社區(qū)內(nèi)聯(lián)系廣大業(yè)主，提議召開業(yè)主大會(huì)來得直接。

89 、They convened a panel to convict him.─── 他們召集專門小組給他定罪

90 、Well, we'll convene as soon as she gets here.─── 那我們等她一來就開始開會(huì)

Notch信號(hào)通路解讀

1917年，Morgan及其同事在突變的果蠅中發(fā)現(xiàn)Notch基因，因該基因的部分功能缺失會(huì)在果蠅翅膀的邊緣造成缺刻（Notch）而得名.               該通路由Notch受體、Notch配體（ DSL 蛋白）、CSL （CBF-1，Suppressor of hairless，Lag的合稱）DNA結(jié)合蛋白、其他的效應(yīng)物和Notch的調(diào)節(jié)分子等組成。

哺乳動(dòng)物中有4 個(gè)同源Notch受體和5個(gè)同源配體, 其中同源受體是Notch1-4,同源配體有兩類: Delta 樣配體, 分別為Dll-1、Dll-3、Dll-4; Serrate 樣配體, 分別為Jagged-1 和Jagged-2。

所有的同源Notch受體都是Ⅰ型跨膜蛋白, 均由胞內(nèi)區(qū)、跨膜區(qū)和胞外區(qū)組成。胞內(nèi)區(qū)包含1個(gè)N端RAM結(jié)構(gòu)域、6個(gè)錨蛋白樣重復(fù)序列、2個(gè)核**信號(hào)、1個(gè)轉(zhuǎn)錄激活區(qū)及1個(gè)PEST結(jié)構(gòu)域,胞內(nèi)區(qū)負(fù)責(zé)將Notch信號(hào)轉(zhuǎn)到細(xì)胞核內(nèi)。胞外區(qū)有29～36個(gè)表皮生長(zhǎng)因子樣重復(fù)序列,其中第11、12個(gè)表皮生長(zhǎng)因子樣重復(fù)序列介導(dǎo)與配體的相互作用。同源配體也是Ⅰ型跨膜蛋白,具有數(shù)量不同的表皮生長(zhǎng)因子樣重復(fù)序列, 保守的N端為Notch受體結(jié)合和活化所必需的DSL基序。Serrate樣配體還有一個(gè)富含半胱氨酸區(qū)域, 而Delta樣配體則無此區(qū)域。

Notch信號(hào)通路的激活需要經(jīng)過三步酶切過程：首先在細(xì)胞內(nèi)，合成的受體蛋白單鏈前體分子被高爾基體內(nèi)的furin蛋白酶酶切，酶切位點(diǎn)在Notch跨膜區(qū)胞外端的s1位點(diǎn)，酶切形成的ECN(extracellular Notch domain)和NTM (Notch transmembrane fragment)通過一種ca2+依賴的非共價(jià)鍵結(jié)合在一起，形成異二聚體形式的成熟Notch受體，并轉(zhuǎn)運(yùn)至細(xì)胞表面。當(dāng)配體與胞外區(qū)結(jié)合后，Notch受體在ADAM (a disintegrin and metalloprotease)金屬蛋白酶家族的腫瘤壞死因子-α-轉(zhuǎn)換酶(tumor necrosis factor-α- convening enzyme，TACE)或Kuz(kuzbanian)的作用下，于S2酶切位點(diǎn)發(fā)生第二次酶切，釋放部分胞外片段，剩余的部分粘連在細(xì)胞膜上被稱為“Notch—intro TM”。早老素(presenilin，PS) 依賴的γ-分泌酶進(jìn)行組成性酶切過程，發(fā)生于S3酶切位點(diǎn)。經(jīng)過此步酶切過程，形成可溶性NICD(Notch的胞內(nèi)段) 并轉(zhuǎn)移至核內(nèi)。NICD進(jìn)入細(xì)胞核后，其RAM區(qū)結(jié)合CSL蛋白。NICD與CSL蛋白結(jié)合，將原本“協(xié)同抑制復(fù)合物”轉(zhuǎn)換為“協(xié)同活化復(fù)合物”，并進(jìn)而與DNA形成多蛋白一DNA復(fù)合體，激活相關(guān)基因的表達(dá).

Notch信號(hào)傳導(dǎo)除了通過與CSL結(jié)合發(fā)揮作用外，還可通過非CSL依賴調(diào)控途徑，調(diào)節(jié)相關(guān)基因的表達(dá)。NICD能作用的下游基因多為堿性螺旋一環(huán)一螺旋類轉(zhuǎn)錄因子(basic helix-loop—helix，bHLH)，如果蠅中的分裂增強(qiáng)子(enhancer of split，E／sp1)、哺乳動(dòng)物中的HES以及HERP(HES-related repressor protein)等。

Notch信號(hào)通路的活化主要從以下兩方面導(dǎo)致腫瘤形成：1、誘導(dǎo)促生長(zhǎng)基因如cyclin D1和C-myc的表達(dá)；2、觸發(fā)P13激酶/AKT等抗凋亡通路；此外，在一些組織中，Notch有促進(jìn)組織生長(zhǎng)和組織的自我更新以及維持干細(xì)胞的未分化狀態(tài)的功能。

求一篇以a time of change為題的英語(yǔ)演講稿，二分鐘左右。

time of changeOctober 15, 2007 to 21, the world's 17 major Chinese Communist victory in Beijing was held at the conference, Comrade Hu Jintao made a speech entitled "to hold high the great banner of socialism with Chinese characteristics to capture a well-off society and strive for new victories," report. The theme is: to hold high the great banner of socialism to Deng Xiaoping Theory and "Three Represents" as guidance, in-depth implementation of the scientific concept of development, continue to emancipate the mind, persist in reform and opening up, promote scientific development, promote social harmony, for to win a well-off society and strive for new victories. The General Assembly agreed to the scientific concept of development into the party constitution. Communist China also raised the 17 largest fifteen years of compulsory education, which is more exciting and looks forward to the news. On that day, the students have discussions at their mutual transmission of the news, as well as our teachers told us the news. After school, I could not wait to tell the parents and sister, but sister has doubts and said: "When? I do not know how long, and you and I could work out." Hesitation I replied: "is it? Should not Goodbye! may not benefit us, but also --------" father said: "On one occasion, not to say that is free to implement it? implementation of the results up to now only a part of the region free of charge, when they could do primary and secondary schools throughout the country the case? "So, I implemented the program for those who are also dissatisfied with the pace, but I also respect and look forward to the proposed 17 large and medium-sized, really hope that he can as soon as possible. People-oriented, comprehensive, coordinated and sustainable development of the scientific concept of development. In contemporary China, adhering to Marxism-Leninism, Mao Zedong Thought, Deng Xiaoping Theory and "Three Represents", it is necessary to firmly establish and fully implement the scientific concept of development. Therefore, it is written into the constitution is a wise choice. I know that this is since the party's National Congress in order to Hu Jintao as general secretary of the Chinese Communist Party, the party and the people focus on the development of the overall situation, closely focusing on building socialism with Chinese characteristics of this theme, constantly sum up experience and the formation of the scientific development concept . As science advances, the development of productive forces, and then gradually the rich people's lives up. Unfair because the rich people's lives has been the development of productive forces, raised, but also because unswervingly adhere to the party in the primary stage of socialism's basic line. "Reform is the driving force, development is the last word, stability overrides everything else." Reformer is the essence of the socialist system of self-improvement and development of economic and social development of a powerful driving force. The fundamental purpose of reform is to form in all respects with the basic national conditions of the primary stage of socialism suited to more mature, more stereotyped system of socialism with Chinese characteristics, it is full of vigor and vitality. Grandpa of Deng Xiaoping once said: "firm grip on the party's" main center, two basic points "of the basic line, and never waver in one hundred years, the state will be able to long-term stability, China has been promising." Since reform and opening up, our lives would be thriving today. Clothing: In the past, grandparents generation, regardless of how the kind of style, how新舊程度, as long as the clothes. They will be very happy. In those days, clothing is very急缺, and in many families, usually through his brother, and left his brother to wear, and sometimes a two people take turns to wear pants. These are said to listen to my grandfather. But now society has developed, people's lives changed for the better material, and clothes are not missing, as in the past do not need a. Now is not the people, ah do not wear fashionable, rather than brand-name non-wearing. Today, our life is not only rich but also to understand the artistic beauty. Fresh: The mother's father's generation, as long as there has been very good to eat by. I heard my mother said that in their year's opportunity to eat pork is almost impossible, they eat most of the sweet potatoes. But now we not only eat about its taste, but also about its packaging. This is not a show of China's economic development. Live: in the older generation of that time, many people no place to live, as long as there is a local遮風(fēng)擋雨on the already very good, and how can live together regardless of how many people, how does the structure of housing. But now the rich people's lives and economic conditions changed for the better, and also to live a new stress. Houses have become more sophisticated, more and more the United States. Line: in the old China, people go to a distant place most of them are more坐馬車walk or ride a bike or, therefore, is very inconvenient journey. But now is different, social progress and scientific development, and improved economic conditions, aircraft, ah, train, ah, ah car so transport is also more, go to visit relatives, shopping, tourism is also much more convenient, more comfortable. Therefore, it is more and more people around to different places to see to see. To see the prosperity of the society, I believe that the convening of a large 17 and under the leadership of the party, people's lives will have a brighter future, eventually building a moderately prosperous society to achieve this goal2007年10月15日至21日，舉世矚目的中共十七大在北京勝利召開，胡錦濤同志在大會(huì)上作了題為《高舉中國(guó)特色社會(huì)主義偉大旗幟為奪全面建設(shè)小康社會(huì)新勝利而奮斗》的報(bào)告。大會(huì)的主題是：高舉特色社會(huì)主義偉大旗幟，以鄧小平理論和“三個(gè)代表”重要思想為指導(dǎo)，深入貫徹落實(shí)科學(xué)發(fā)展觀，繼續(xù)解放思想，堅(jiān)持改革開放，推動(dòng)科學(xué)發(fā)展，促進(jìn)社會(huì)和諧，為奪取全面建設(shè)小康社會(huì)新勝利而奮斗。大會(huì)一致同意將科學(xué)發(fā)展觀寫入黨章。 中共十七大還提出了十五年的義務(wù)教育，這是更令人興奮和期待的消息了。在那天，同學(xué)分們紛紛議論相互傳遞這消息，還有我們的老師也跟我們說了這個(gè)消息。放學(xué)后，我迫不及待地告訴了父母和姐姐，但姐姐卻疑惑地說：“實(shí)施時(shí)？不知要多久了，你我都有可能出來工作了。”我遲疑地答道：“是嗎？應(yīng)該不會(huì)吧！雖然不能惠及我們，但也--------”爸爸說：“有一次，不是說要實(shí)施全免嗎？結(jié)果到現(xiàn)在實(shí)行只是免費(fèi)一部分地區(qū)，到什么時(shí)候才能做到遍及全國(guó)的中小學(xué)了呢？”因此，我對(duì)那些方案的實(shí)施速度也比較不滿，但我也十分尊敬和期待十七大中所提出的，也希望他能盡快落實(shí)。 以人為本，全面協(xié)調(diào)可持續(xù)發(fā)展的科學(xué)發(fā)展觀。在當(dāng)代中國(guó)，堅(jiān)持馬克思列寧主義、**思想、鄧小平理論和“三個(gè)代表”重要思想，就必須牢固樹立和全面落實(shí)科學(xué)發(fā)展觀。所以把它寫入黨章是個(gè)明智的選擇。我知道這是黨的十六大以來，以胡錦濤為**的黨中共，著眼于黨和人民事業(yè)發(fā)展的全局，緊緊圍繞建設(shè)中國(guó)特色社會(huì)主義這個(gè)主題，不斷總結(jié)經(jīng)驗(yàn)，形成了科學(xué)發(fā)展觀。因?yàn)榭茖W(xué)的發(fā)達(dá)，生產(chǎn)力發(fā)展了，人民生活隨之逐漸富裕起來了。人民生活富裕不公因?yàn)樯a(chǎn)力發(fā)展了、提高了，更是因?yàn)楹敛粍?dòng)搖地堅(jiān)持黨在社會(huì)主義初級(jí)階段的基本路線。“改革是動(dòng)力，發(fā)展是硬道理，穩(wěn)定壓倒一切?！备母镎叩膶?shí)質(zhì)是社會(huì)主義制度的自我完善和發(fā)展，是經(jīng)濟(jì)和社會(huì)發(fā)展強(qiáng)大動(dòng)力。改革的根本目的就是要在各方面形成與社會(huì)主義初級(jí)階段基本國(guó)情相適應(yīng)比較成熟的、比較定型的制度，它使中國(guó)特色社會(huì)主義充滿了生機(jī)和活力。鄧小平爺爺出曾經(jīng)說過：“牢牢把握黨的“主個(gè)中心，兩個(gè)基本點(diǎn)”的基本路線，一百年不動(dòng)搖，國(guó)家就能長(zhǎng)治久安，中國(guó)就大有希望了?！?因?yàn)楦母镩_放，我們的生活才會(huì)有今天的欣欣向榮。 衣：以前爺爺奶奶那一代，不管款式是怎么樣的、新舊程度如何，只要有衣服穿。他們就會(huì)十分高興了。在那個(gè)年代，衣服是非常急缺的，在很多家庭里，通常哥哥穿過的，留給弟弟穿，有時(shí)還一條褲子兩個(gè)人輪流穿。這些都是聽我外公說的。但現(xiàn)在社會(huì)發(fā)展了，人們的生活物質(zhì)變好了，衣服也不缺了，也不需要像以前那樣了?，F(xiàn)在的人啊不是時(shí)髦的不穿，不是名牌的不穿了。今天，我們的生活不僅富裕而且還懂得了藝術(shù)美。 食：在爸爸媽媽的那一代，只要有吃的就已經(jīng)很好了。我聽媽媽說，在她們那個(gè)年代一年中吃到豬肉的機(jī)會(huì)幾乎是沒有，她們每天吃的大多數(shù)是蕃薯?？墒乾F(xiàn)在我們對(duì)吃的不僅講究它的味道，也講求它的包裝。這不是說明了我國(guó)經(jīng)濟(jì)發(fā)展了。 ?。涸诶弦惠叺哪莻€(gè)年代，很多人都沒地方住，只要有個(gè)地方遮風(fēng)擋雨就已經(jīng)很不錯(cuò)了，哪能管它多少人一起住，房屋的構(gòu)造如何呢。但現(xiàn)在人們的生活富裕的，經(jīng)濟(jì)條件變好了，對(duì)住方面也有了新的講究。房子也越來越高，越來越美。 行：在舊中國(guó)的時(shí)候，人們?nèi)ヒ粋€(gè)比較遠(yuǎn)的地方大多數(shù)都是步行或者是坐馬車更或者是騎自行車，因此，出遠(yuǎn)門都很不方便。可是現(xiàn)在就不同了，社會(huì)進(jìn)步了，科學(xué)發(fā)展了，經(jīng)濟(jì)條件提高了，飛機(jī)啊、火車啊、汽車啊等等交通工具也多了，出門探親、逛街、旅游也方便多了，舒服多了。因此，現(xiàn)在越來越多的人去不同的地方走走，去見識(shí)見識(shí)。 看到這樣繁榮昌盛的社會(huì)，我相信十七大的召開，并且在黨的領(lǐng)導(dǎo)下，人民的生活會(huì)更加美好，最終也會(huì)實(shí)現(xiàn)全面建設(shè)小康社會(huì)這一項(xiàng)目標(biāo)。